Uaya Botanicals 2:1 CBD:THC Tincture 1500 mg (FULL SPECTRUM)

Uaya Botanicals 2:1 CBD:THC Tincture (1500 mg Total) is a high-potency, full-spectrum sublingual liquid formulation containing a balanced ratio of two parts cannabidiol (CBD) to one part $\Delta^9$-tetrahydrocannabinol ($\Delta^9$-THC).

Carried in organic medium-chain triglyceride (MCT) oil, this tincture is formulated to leverage the “entourage effect”—where primary cannabinoids, minor cannabinoids (CBG, CBN, CBC), and natural plant terpenes act synergistically to enhance therapeutic efficacy while CBD moderates the psychotropic intensity of THC.

1. Cannabinoid Breakdown & Volumetric Dosing

The 1500 mg total active cannabinoid concentration is distributed in a precise 2:1 ratio across a standard 30 mL volume container.

                    [1500 mg Bottle Breakdown]
                    
  Total Volume             : 30 mL (1 Fl. Oz.)
  Total Cannabinoid Mass   : 1500 mg (1000 mg CBD + 500 mg THC)
  Concentration Per 1 mL   : 33.3 mg CBD  +  16.6 mg THC (~50 mg Total/mL)
  Concentration Per Dropper: ~0.83 mg CBD + ~0.41 mg THC per single drop

• CBD Component (1000 mg): Non-intoxicating, negative allosteric modulator of $\text{CB}_1$ receptors. It mitigates THC-induced tachycardia, anxiety, and cognitive impairment.

• $\Delta^9$-THC Component (500 mg): Primary psychoactive cannabinoid acting as a partial agonist at $\text{CB}_1$ and $\text{CB}_2$ receptors, providing analgesia, muscle relaxation, appetite stimulation, and sedation.

• Full-Spectrum Extract: Contains trace native terpenes (myrcene, beta-caryophyllene, linalool) and minor cannabinoids that support bioavailability and overall therapeutic response.

2. Dosing Protocols & Pharmacokinetics

Sublingual administration bypasses initial hepatic first-pass metabolism, offering a faster onset and higher bioavailability than solid edible products.

                 [Sublingual vs Oral Edible Onset]
                 
  Sublingual Hold (60–90s) : Onset 15 to 45 mins  |  Duration 4 to 6 hours
  Swallowed / Oral         : Onset 60 to 90 mins  |  Duration 6 to 8 hours

3. Pharmacological Rationale: The 2:1 Synergy

The 2:1 CBD:THC ratio is widely utilized in medical cannabis paradigms due to the distinct receptor interactions between the two cannabinoids:

1. Receptor Modulation ($\text{CB}_1$ Regulation): CBD binds to an allosteric site on the $\text{CB}_1$ receptor, altering its conformation and reducing the binding affinity of $\Delta^9$-THC. This significantly lowers the incidence of paranoia, racing heart rate, or intense intoxication often caused by isolated THC.

2. Enhanced Anti-Inflammatory Action: Both CBD and THC target peripheral $\text{CB}_2$ receptors and non-cannabinoid targets (such as TRPV1 and PPAR-$\gamma$), producing superior anti-inflammatory and pain-modulating effects compared to single-molecule isolates.

4. Administration Guidelines & Storage

• Sublingual Application: Place the measured fluid directly under the tongue using the calibrated glass dropper. Hold for 60 to 90 seconds before swallowing to optimize direct mucosal absorption into the bloodstream.

• Titration Protocol: New users should follow the “Start Low, Go Slow” principle, starting at 0.25 mL (4.1 mg THC / 8.3 mg CBD) and waiting at least 2 hours before evaluating the need for a secondary dose.

• Storage Conditions: Store in a cool, dark environment away from direct sunlight and thermal radiation. Exposure to heat and UV radiation converts active $\Delta^9$-THC into CBN (cannabinol) and degrades native terpenes, reducing overall potency.

  Made with the cleanest hemp distillate on the market, our full spectrum 2:1 (CBD-THC) is sure to pack a punch to knockout even your toughest symptoms.

  INGREDIENTS: Full Spectrum Hemp Oil Distillate –  Is a highly refined CBD extract derived from hemp biomass. CBD Distillate typically contains significant quantities of other cannabinoids including CBG, CBC and THC. Organic MCT Oil – Aids in digestion and can help heal digestive disorders, as well as brain function, metabolic functions, weight loss, arthritis and bone health. Natural Terpenes – Are organic compounds that provide aroma and flavor in cannabis and a variety of other organisms, including plants. Terpenes are responsible for the aroma and flavors of cannabis, and influence its effects by interacting with cannabinoids.

  DOSAGE: We recommend starting with a quarter to a half dropper (0.25 – 0.5ml) and increasing as needed. Individual results may vary. Use Daily.